{"id":7983,"date":"2010-10-01T00:00:19","date_gmt":"2010-10-01T00:00:19","guid":{"rendered":"http:\/\/cellgenuity.com\/?p=7983"},"modified":"2018-06-28T18:38:19","modified_gmt":"2018-06-28T18:38:19","slug":"human-amnion-as-a-temporary-biologic-barrier-after-hysteroscopic-lysis-of-severe-intrauterine-adhesions-pilot-study","status":"publish","type":"post","link":"https:\/\/cellgenuity.com\/index.php\/2010\/10\/01\/human-amnion-as-a-temporary-biologic-barrier-after-hysteroscopic-lysis-of-severe-intrauterine-adhesions-pilot-study\/","title":{"rendered":"Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study"},"content":{"rendered":"<div id=\"block-yui_3_17_2_6_1510095114584_349107\" class=\"sqs-block markdown-block sqs-block-markdown\" data-block-type=\"44\">\n<div class=\"sqs-block-content\">\n<p><strong>Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study\u00a0<\/strong><\/p>\n<p><a href=\"http:\/\/cellgenuity.com\/wp-content\/uploads\/2018\/05\/human-amnion-as-a-temporary-biologic-barrier-after-hysteroscopic-lysis-of-severe-intrauterine-adhesions-pilot-study.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-8031\" src=\"http:\/\/cellgenuity.com\/wp-content\/uploads\/2018\/05\/cellgenuitydownloadlogo-150x150.png\" alt=\"\" width=\"150\" height=\"150\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<div id=\"block-yui_3_17_2_6_1510095114584_347768\" class=\"sqs-block html-block sqs-block-html\" data-block-type=\"2\">\n<div class=\"sqs-block-content\">\n<p>J Minim Invasive Gynecol. 2010 Sep-Oct;17(5):605-11. doi: 10.1016\/j.jmig.2010.03.019. Epub 2010 Jun 23.<\/p>\n<p>Amer MI1, Abd-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS.<br \/>\n1Department of Obstetrics and Gynecology, Ain Shams University, Helliopolis, Cairo, Egypt.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>STUDY OBJECTIVE<\/strong>: To estimate the efficacy of fresh and dried amnion graft after hysteroscopic lysis of severe intrauterine adhesions in decreasing its recurrence and encouraging endometrial regeneration.<\/p>\n<p><strong>DESIGN<\/strong>: Pilot prospective randomized comparative study (Canadian Task Force classification I).<\/p>\n<p><strong>SETTING<\/strong>: Ain Shams Medical School, Cairo, Egypt.<\/p>\n<p><strong>PATIENTS<\/strong>: Forty-five patients with severe intrauterine adhesions. Primary symptom was infertility with or without menstrual disorders such as amenorrhea or hypomenorrhea.<\/p>\n<p><strong>INTERVENTIONS<\/strong>: Patients were randomized preoperatively using a computer-generated randomization sheet into 3 groups of 15 patients each. Allocation to any group was concealed in an opaque envelope, which was opened at the time of operation. Hysteroscopic lysis of intrauterine adhesions was followed by insertion of an intrauterine balloon only (group 1) or either fresh amnion graft (group 2) or dried amnion graft (group 3) for 2 weeks. Diagnostic hysteroscopy was performed at 2 to 4 months postoperatively.<\/p>\n<p><strong>MEASUREMENTS AND MAIN RESULTS<\/strong>: Adhesion grade, menstruation, uterine length, complications, and reproductive outcome were determined. There was significant improvement in adhesion grade with amnion graft vs intrauterine balloon alone (p = .003). Improvement was greater with fresh amnion than with dried amnion (p = .01). Normal menstruation occurred in 4 patients (28.6%) in group 1, 5 (35.7%) in group 2, and 7 (46.7%) in group 3. Of 43 patients, 41 (95.3%) were treated in 2 endoscopic sessions (95.3%), and 2 patients (4.7%) were treated in 3 endoscopic sessions. Uterine perforations occurred in 2 patients (4.7%), and cervical tears in 3 (7.0%). Ten patients (23.3%) achieved pregnancy, 8 (80%) after amnion graft and 2 (20%) without amnion. Six of the 10 patients (60%) miscarried, and 4 (40%) were either still pregnant or delivered at term without complications.<\/p>\n<p><strong>CONCLUSION<\/strong>: Hysteroscopic lysis of severe intrauterine adhesions with grafting of either fresh or dried amnion is a promising adjunctive procedure for decreasing recurrence of adhesions and encouraging endometrial regeneration.<\/p>\n<p>Copyright \u00a9 2010 AAGL. Published by Elsevier Inc. All rights reserved.<br \/>\nPMID: 20576472 [PubMed \u2013 indexed for MEDLINE]\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study\u00a0 J Minim Invasive Gynecol. 2010 Sep-Oct;17(5):605-11. doi: 10.1016\/j.jmig.2010.03.019. Epub 2010 Jun 23. Amer MI1, Abd-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS. 1Department of Obstetrics and Gynecology, Ain Shams University, Helliopolis, Cairo, Egypt. Abstract STUDY OBJECTIVE: To estimate the [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pgc_meta":"","footnotes":""},"categories":[62,26,61,63,65,64],"tags":[],"class_list":["post-7983","post","type-post","status-publish","format-standard","hentry","category-biologic-barrier","category-gynecology","category-human-amnion","category-hysteroscopic-lysis","category-pilot-study","category-severe-intrauterine-adhesions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study - CellGenuity | Welcome to CellGenuity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cellgenuity.com\/index.php\/2010\/10\/01\/human-amnion-as-a-temporary-biologic-barrier-after-hysteroscopic-lysis-of-severe-intrauterine-adhesions-pilot-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study - CellGenuity | Welcome to CellGenuity\" \/>\n<meta property=\"og:description\" content=\"Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions pilot study\u00a0 J Minim Invasive Gynecol. 2010 Sep-Oct;17(5):605-11. doi: 10.1016\/j.jmig.2010.03.019. Epub 2010 Jun 23. Amer MI1, Abd-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS. 1Department of Obstetrics and Gynecology, Ain Shams University, Helliopolis, Cairo, Egypt. 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