{"id":7973,"date":"2009-08-18T00:00:17","date_gmt":"2009-08-18T00:00:17","guid":{"rendered":"http:\/\/cellgenuity.com\/?p=7973"},"modified":"2018-06-28T19:15:51","modified_gmt":"2018-06-28T19:15:51","slug":"implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions","status":"publish","type":"post","link":"https:\/\/cellgenuity.com\/index.php\/2009\/08\/18\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions\/","title":{"rendered":"Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions"},"content":{"rendered":"<div id=\"block-yui_3_17_2_6_1510095114584_239306\" class=\"sqs-block markdown-block sqs-block-markdown\" data-block-type=\"44\">\n<div class=\"sqs-block-content\">\n<p><strong>Implantation of amniotic membrane to reduce\u00a0postlaminectomy epidural adhesions <\/strong><\/p>\n<p><a href=\"http:\/\/cellgenuity.com\/wp-content\/uploads\/2018\/05\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-thumbnail wp-image-8031\" src=\"http:\/\/cellgenuity.com\/wp-content\/uploads\/2018\/05\/cellgenuitydownloadlogo-150x150.png\" alt=\"\" width=\"150\" height=\"150\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<div id=\"block-yui_3_17_2_6_1510095114584_239369\" class=\"sqs-block html-block sqs-block-html\" data-block-type=\"2\">\n<div class=\"sqs-block-content\">\n<p>Eur Spine J. 2009 Aug;18(8):1202-12. doi: 10.1007\/s00586-009-1013-x. Epub 2009 Apr 30.<\/p>\n<p>Tao H1, Fan H.<br \/>\n1Department of Orthopaedics and Traumatology, Xi-jing Hospital, The Fourth Military Medical University, 710032, Xi\u2019an, China.<\/p>\n<p><strong>Abstract<\/strong><br \/>\nPostlaminectomy epidural adhesion is implicated as a main cause of \u201cfailed back surgery syndrome\u201d and associated with increased risk of complications during revision surgery. Various materials acting as mechanical barriers to reduce fibroblasts infiltration into epidural space have met with limited success. In present research, amniotic membrane (AM) was studied to investigate its effects on reducing epidural scar adhesion after laminectomy in a canine model. Laminectomy sites were created at L-1, L-3, L-5, and L-7 levels in 24 adult mongrel dogs. Freeze dried AM (FAM), cross-linked AM (CAM), and autologous free fat (AFF) were implanted, respectively, at a randomly assigned site in each dog with the remaining untreated site serving as internal control. The animals were sacrificed at 1, 6, and 12 weeks postoperatively. Then, gross pathologic observation including scar amount and adhesion tenacity, qualitative histology evaluation, and quantitative histology analysis were compared. Gross observation demonstrated that scar amount and adhesion tenacity of CAM group were significantly lower in comparison with those of FAM and non-treatment groups. A white, slightly vascularized CAM layer covered the dura mater without tenacious scar adhesion. The histology analysis also indicated reduced fibroblasts infiltration and consequent epidural fibrosis, which were similar to the results of AFF group. In conclusion, the CAM is effective in reducing epidural fibrosis and scar adhesion after laminectomy in canine model. It is a promising biomaterial for future clinical applications.<\/p>\n<p>PMID: 19404691 [PubMed \u2013 indexed for MEDLINE] PMCID: PMC2899499<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Implantation of amniotic membrane to reduce\u00a0postlaminectomy epidural adhesions Eur Spine J. 2009 Aug;18(8):1202-12. doi: 10.1007\/s00586-009-1013-x. Epub 2009 Apr 30. Tao H1, Fan H. 1Department of Orthopaedics and Traumatology, Xi-jing Hospital, The Fourth Military Medical University, 710032, Xi\u2019an, China. Abstract Postlaminectomy epidural adhesion is implicated as a main cause of \u201cfailed back surgery syndrome\u201d and associated [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pgc_meta":"","footnotes":""},"categories":[56,74,18,25,76,73,24],"tags":[],"class_list":["post-7973","post","type-post","status-publish","format-standard","hentry","category-amniotic-membrane","category-epidural-adhesion","category-fibrosis","category-general-surgery","category-implantation","category-reduce-postlaminectomy","category-spine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions - CellGenuity | Welcome to CellGenuity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cellgenuity.com\/index.php\/2009\/08\/18\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions - CellGenuity | Welcome to CellGenuity\" \/>\n<meta property=\"og:description\" content=\"Implantation of amniotic membrane to reduce\u00a0postlaminectomy epidural adhesions Eur Spine J. 2009 Aug;18(8):1202-12. doi: 10.1007\/s00586-009-1013-x. Epub 2009 Apr 30. Tao H1, Fan H. 1Department of Orthopaedics and Traumatology, Xi-jing Hospital, The Fourth Military Medical University, 710032, Xi\u2019an, China. Abstract Postlaminectomy epidural adhesion is implicated as a main cause of \u201cfailed back surgery syndrome\u201d and associated [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cellgenuity.com\/index.php\/2009\/08\/18\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions\/\" \/>\n<meta property=\"og:site_name\" content=\"CellGenuity | Welcome to CellGenuity\" \/>\n<meta property=\"article:published_time\" content=\"2009-08-18T00:00:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-06-28T19:15:51+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/cellgenuity.com\/wp-content\/uploads\/2018\/05\/cellgenuitydownloadlogo-150x150.png\" \/>\n<meta name=\"author\" content=\"CellGenuity\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"CellGenuity\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cellgenuity.com\/index.php\/2009\/08\/18\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions\/\",\"url\":\"https:\/\/cellgenuity.com\/index.php\/2009\/08\/18\/implantation-of-amniotic-membrane-to-reduce-postlaminectomy-epidural-adhesions\/\",\"name\":\"Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions - 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