Effect of amniotic membrane to reduce postlaminectomy epidural adhesion on a rat model
J Korean Neurosurg Soc. 2011 Jun;49(6):323-8. doi: 10.3340/jkns.2011.49.6.323. Epub 2011 Jun 30.
Choi HJ1, Kim KB, Kwon YM.
1Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea.
OBJECTIVE: Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
METHODS: A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
RESULTS: The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
CONCLUSION: This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
PMID: 21887388 [PubMed] PMCID: PMC3158473